Development and Characterization of VEGF165-Chitosan Nanoparticles for the Treatment of Radiation-Induced Skin Injury in Rats

Development and Characterization of VEGF165-Chitosan Nanoparticles for the Treatment of Radiation-Induced Skin Injury in Rats

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Radiation-induced skin injury, which remains a serious concern in radiation Saw Palmetto therapy, is currently believed to be the result of vascular endothelial cell injury and apoptosis.Here, we established a model of acute radiation-induced skin injury and compared the effect of different vascular growth factors on skin healing by observing the changes of microcirculation and cell apoptosis.Vascular endothelial growth factor (VEGF) was more effective at inhibiting apoptosis and preventing injury progression than other factors.

A new strategy for improving the bioavailability of vascular growth factors was developed by loading VEGF with chitosan nanoparticles.The VEGF-chitosan nanoparticles showed a protective effect on vascular endothelial Gift Cards cells, improved the local microcirculation, and delayed the development of radioactive skin damage.